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Effect of Mimosine from Vietnamese Mimosa pudica L. in carrageenan-induced arthritic mouse model

Description: Mimosine is an active component of Mimosa pudica L. Pharmacological activities of Mimosine from Mimosa pudica L. have been demonstrated in vitro and in vivo. In this study, we examined the role of Mimosine during the regulation of in vitro inflammatory signaling in macrophage and in vivo anti-inflammation of mice with carrageenan-induced arthritis.

Rheumatoid arthritis (RA) is an autoimmune disease in which the body's immune system attacks joint tissue, causing inflammation of the joint lining leading to cartilage degradation. The treatment objectives of RA are to reduce inflammation, inhibition of pannus formation and morphological variation, as well as long term pain relief. The drugs used to treat rheumatoid arthritis reduce those biological mechanisms which are involved in the inception of the inflammatory response.

Organisation: Research Institute of Creative Education

Innovator(s): Le An Bich Phuong, Le Thieu Han, Pham Quoc Anh, Hoang Xuan Tung

Category: Biotechnology

Country: Vietnam

Gold Award