Description: 'UROGRAFT- implant for the urinary bladder reconstruction', is an innovative Advanced Therapy Medicinal Product (ATMP) composed of a biodegradable composite scaffold and Mesenchymal Stem/Stromal Cells (MSCs) recommended for patients requiring urinary tract reconstruction.
There are many congenital and acquired conditions that require urinary bladder reconstruction. The most frequent cases are neurological dysfunctions, chronic inflammations, congenital and developmental defects of the urinary tract and traumas. The most frequently used material for the urinary bladder reconstruction is an intestinal wall. However, the use of this material induces many complications. At the moment there is no commercially available medical device or Advanced Therapy Medicinal Product (ATMP) for the reconstruction of the urinary tract, which would replace autologous material (intestinal wall). UROGRAFT is an invention developed by the team led by Prof. Pokrywczyńska for the reconstruction of the human urinary bladder. The UROGRAFT is an innovative product made of a biodegradable composite scaffold characterised by biological and mechanical properties similar to the native human urinary bladder wall. There are two available variants of the UROGRAFT: an acellular product and in combination with Adipose-Derived Mesenchymal Stem/Stromal Cells (AD-MSCs). The UROGRAFT is a fully tested in vitro and in vivo product ready to use in a clinical study. The product is characterised by its unique bioconfiguration, favourable 3D structure, very good biocompatibility and high regenerative potential. The UROGRAFT is an opportunity to improve the quality of life for patients requiring urinary bladder reconstruction.
Organisation: Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń
Innovator(s): Chair of Urology and Andrology, Collegium Medicum UMK, Bydgoszcz: Prof. Marta Pokrywczyńska; Jan Adamowicz, MD, DSc; Arkadiusz Jundziłł, MD, DSc; Tomasz Kloskowski, PhD; Marta Rasmus, MSc; Daria Balcerczyk, MSc; Zuzanna Fekner, MSc; Chair of Biomaterials and Cosmetic Chemistry UMK Toruń: Marta Szulc, MSc; Bydgoszcz University of Science and Technology: Michał Stopel, PhD
Category: Medicine, Biotechnology and Medical Devices