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TRITERPENOID FROM COMBRETUM TRIFOLIATUM COLLECTED IN VIETNAM

Description: For the first time, the phytochemical investigation of Combretum trifoliatum was examined and led to segregation and purification of two triterpenoids, betulinic acid (1), and mollic acid (2) by different methods of chromatography. Their chemical structures were elucidated using HR-ESI-MS, and NMR assignments, and comparison with those data of published papers. For the first time, two compounds (1 & 2) were identified from this species.

This is the first time the chemical composition of Combretum trifoliatum leaves has been studied. The study has isolated and determined the structure of two triterpenoids, betulinic acid (CTE.01), and mollic acid (CTE.02). Although these compounds have been confirmed from the other species of the genus Combretum, this is the first time that has been affirmed from C. trifoliatum. Previous studies were demonstrated betulinic acid has the cytotoxicity against many cancer cell lines and causes very strong toxicity without harm normal cells and potential as an effective cancer cure [5, 11], mollic acid has the cytotoxic effect against HeLa with IC50= 34.74 μM [12]. For the first time, this project initially studied triterpenoid components of the Combretum trifoliatum leaves which expressed cytotoxicity can be used in the reduction and treatment of cancer. The project isolated and identified two triterpenoids, namely betulinic acid, and mollic acid which have good cytotoxicity, initially, elucidating the chemical composition, enhancing the use-value of Combretum trifoliatum and suggestive to the further research on the composition of bioactive ingredients as well as the mechanism of action of those in cancer treatment and support.

Organisation: Research Institute of Creative Education (RICE)

Innovator(s): Nguyen Hoang Thai Son, Dang Vu Bao Tran, Le Khue Tu

Category: Young inventors

Country: Vietnam

Gold Award